NeriumAD Now and in the Future

http://www.neriumbiotech.com/product.htm

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Nerium Biotechnology, Inc. (Nerium) is dedicated to offering solutions that are based on proven science and actual customer success. Our natural botanical products offered to the consumer are founded on the continuing research at leading medical institutions using the latest scientific methods and technology. Utilizing biotechnology research and new breakthrough extraction technology, Nerium is continuing to developing a complete line of products that harnesses Nerium oleander's unique and effective properties.

Products: US-based Operations

Nerium SkinCare, Inc. a subsidiary of Nerium Biotechnology, Inc., develops, formulates, and manufactures for the consumer the “first of its kind” natural skincare products for topical use. Nerium SkinCare’s products are founded the on the technology, core science, and continuing research of Nerium Biotechnology, Inc.

Product Distribution
Nerium SkinCare is excited to announce that distribution for products have been provided for through a new exclusive licensing partnership between Nerium SkinCare, Inc. and Nerium International, LLC.

New Technology
Nerium SkinCare utilizes Nerium’s new patent-pending extraction technologyNBio-PL² ™ for its skincare products. This extraction technology incorporates pure liquid Aloe Vera (cold processed) to extract the unique Nerium oleander plant components in a way that preserves the unique and beneficial properties of both plants, without additional solvents. The results of this new technology Nerium Extract NAE-8™ has allowed Nerium SkinCare to formulate and develop the "first of its kind", age-defying night cream (NeriumAD™) cold sore/fever blister lip therapy (NeriumCS™) and skin repair cream (NeriumDerm™) for topical applications.

Safety and Clinical Testing
Testing for product safety and clinical application was initiated with Science, Toxicology & Technology, Inc. (ST&T Research). ST&T Research is comprised of a group of prominent scientist, including M.D. and Ph.D. pharmacologists/toxicologist and research product development oriented physicians, scientist, and regulatory compliance specialists which include a legal team specializing in US FDA/FTC/Customs regulations. ST&T Research provides product development, product compliance, regulatory compliance, clinical testing, and information and data for safety and efficacy. Dr. Newman who serves as a scientific advisor to Nerium SkinCare assisted by providing safety data from previous studies, experience from a FDA cancer trial at The University of Texas M. D. Anderson Cancer Center, and the analytical analysis for the determination of oleandrin (CG) in blood plasma.

New Product Development, Testing, and Launch
Nerium SkinCare has formulated/developed its initial new product for market launch, NeriumAD™ an age –defying treatment (Night Cream). Exclusive distribution of NeriumAD™ is provided for in partnership with Nerium International, LLC.

Anti-aging skin creams are abundant in today's cosmetic marketplace. New ingredients that may provide additional efficacy are sought to improve existing products. The NeriumAD™ formulation is specifically designed for this market and provides two (2) such ingredients, NAE-8™ extract and a proprietary protein blend (collagen & elastin & glycosaminoglycans).Top

Nature Based and Scientifically Developed

Future product development includes:

• NeriumAD Eye Cream
• NeriumAD Age-Spot Cream
• NeriumDerm Skin Repair Cream
• NeriumDerm Blemish Cream
• NeriumDerm Moisturizing Lotion
• NeriumDerm Contouring Lotion
• NeriumDerm Burn Ointment
• NeriumDerm After- Sunburn Skin Lotion
• NeriumDerm Radiation Burn Cream
• NeriumCS Lip Serum

Products: Latin American Operations

The Salud Integral Group, a division of Nerium Biotechnology, Inc. is based in Tegucigalpa, Honduras and integrates the manufacturing, marketing, sales and distribution of products through the Salud Integral, S.A de C.V. Medical Clinic.

Anvirzel™
Anvirzel™ is an internationally patented aqueous extract of Nerium oleander composed of both polar and non-polar compounds, and containing at least five polysaccharides, two cardiac glycosides, and five proteins.

"Anvirzel™, an aqueous extract of the ornamental plant Nerium oleander, contains oleandrin as a principal cytotoxic component. Anvirzel™ has pharmacologic activities against human tumor cells. For example, in addition to its established ability to inhibit Na+, K+ -ATPase activity, this compound is known to result in induction of apoptosis, produce a sustained increase in [Ca2+], inhibit activation of NF-KB, release cytochrome C, activate caspase-dependent pathways, PARP cleavage, and produce persistent cell signal transduction events including activation of MAPK pathway, Racl, p21-activated kinase, and c-Jun NH2-terminal kinase pathways." Journal of Experimental Therapeutics and Oncology. New science, "Oleandrin can also induce cell death through autophagy." Integrated Cancer Therapies (www.saludintegral.hn).

Nerium also is transitioning from the administration of Anvirzel™ as a therapeutic agent by intramuscular injection to the development of Nerium oleander-based products that are administered orally. Nerium believes that its research has demonstrated that an effective oral route of administration for Nerium oleander-based therapeutic agents is feasible.

HIviral™ - HEP-viral™
Two additional Nerium oleander-based products, have been granted Sanitary Registers by the Health Ministry of the Republic of Honduras: HIviral for the treatment of HIV/AIDS and HEP-viral for treatment of hepatitis C. Like Anvirzel™, they are distributed through Nerium Biotechnology’s Latin American subsidiaries.